Thermo Fisher Scientific frequently releases new assay kits (e.g., the Qubit dsDNA HS Assay Kit or RNA IQ Assay). Newer kits may require updated optical settings or calculation algorithms. Without the latest Qubit 4 fluorometer software update, the instrument might not recognize a brand new assay type, forcing you to enter calibration values manually—a process ripe for user error.

Do not touch the power button. The screen will go dark, then reboot automatically. You may see a progress bar. This takes approximately 60 to 90 seconds. When the home screen reappears, repeat Step 1 to verify the version number has changed.

The most recent Qubit 4 fluorometer software update (as of this writing) brings several quality-of-life improvements that seasoned users rave about.

: Plug the USB drive into one of the USB ports on the back or side of the instrument.