Trap Cagri !new! — Fc 433 Star

The Fc 433 Star Trap Cagri is a next-generation conjugate where Cagrilintide is attached to an engineered Fc 433 fragment using Star Trap technology. The result is a once-weekly or potentially once-monthly injectable with unprecedented stability and potency.

In peptide chemistry and receptor pharmacology, a "Star Trap" refers to a molecular configuration where a peptide ligand is engineered to have multiple points of attachment (like the points of a star) to a carrier protein. This design "traps" the peptide in a specific conformation, preventing rapid enzymatic degradation and renal clearance. Essentially, the Star Trap technology extends the half-life of fragile peptides from minutes to days. Fc 433 Star Trap Cagri

The "Fc" stands for "Fragment crystallizable" region—a portion of an antibody. When you see "Fc 433," it typically denotes a specific engineered variant of the Fc domain (likely 433 amino acids in length or a specific mutation at position 433). This fragment acts as the central hub of the Star Trap. By fusing a therapeutic peptide to this Fc 433 scaffold, researchers create a large, stable molecule that avoids filtration by the kidneys and evades immune detection. The Fc 433 Star Trap Cagri is a